Product Size
50 mg
10 mg
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Product Overview
Description
Potent p38 MAPK inhibitor.
Biological Description
Potent p38 MAPK inhibitor (IC50 = 7.1 nM at p38 MAPKα). Additionally inhibits Wnt-3a stimulated β-catenin signaling and shows cross-reactivity with casein kinase Iδ and ε. Antirheumatic. Active in vivo.
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM.
Chemical Properties
Chemical Name
N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
Molecular Weight (Da)
399.51
Molecular Formula
C24H21N3OS
SMILES
CCc2nc(c1cc(C)ccc1)c(s2)c4ccnc(NC(=O)c3ccccc3)c4
Storage & Handling
Storage Instructions
Store at 4 °C. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
