Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent, non-selective LXR agonist.
Biological Description
Potent, non-selective LXR agonist (EC50 = 50 nM). Increases ABCA1 expression associated with cholesterol efflux regulation and HDL metabolism. Increases muscle expression of PPAR-δ. Shows antiobesogenic effects in vivo.
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 100mM.
Chemical Properties
Chemical Name
N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
Molecular Weight (Da)
481.33
Molecular Formula
C17H12F9NO3S
SMILES
O=S(=O)(N(CC(F)(F)F)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c2ccccc2
Storage & Handling
Storage Instructions
Store at 4 °C. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
