STOCK Nubp1^m1Nisw/J

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Cat. No.

CLMM-00270005

Product Type

Age

Sex

Quantity

Mutation Type

Chemically Induced Mutation

Product Overview

These mice carry ENU-induced mutations in Nubp1 (nucleotide binding protein 1)gene which is involved in regulation of centrosome dynamics and microtubule organization, and is essential for lung progenitor survival.

Genetics

Allele Symbol

Nubp1^m1Nisw

Gene Symbol

Nubp1

Gene Name

nucleotide binding protein 1

Phenotype

abnormal digit morphology; oligodactyly; syndactyly; neonatal lethality, complete penetrance

Strain of Origin

C57BL/6J

Chromosome

Molecular Note

ENU induced two C to A transversions at position 743 and 803 resulting in a Threonine to Lysine and Proline to Glutamine amino acid change, respectively. Protein expression is detected in the distal lung epithelium; however the interaction with Nubp2 is disrupted in vitro.

Husbandry

Suggested Controls

Wild-type from the colony

Breeding Considerations

Heterozygotes are viable and fertile. Homozygotes die shortly after birth due to suffocation.

Breeding Strategy

Wild-type x Heterozygote
Heterozygote x Wild-type

For Research Use Only. Not For Clinical Use.