STOCK Kif11^tm1.1Nat/J

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Cat. No.

CLMM-00270012

Product Type

Age

Sex

Quantity

Common Name

Kif11 CKO

Mutation Type

Targeted Mutation

Strain Type

Congenic

Product Overview

Cre recombinase-mediated excision of floxed exons 5 and 6 in these Kif11 CKO mice creates a knock-out allele of the mouse Kif11 (kinesin family member 11) gene. Mutations in the human gene have been associated with syndromic autosomal-dominant microcephaly associated with lymphedema and/or chorioretinopathy, and mental retardation.

Genetics

Allele Symbol

Kif11^tm1.1Nat

Gene Symbol

Kif11

Gene Name

kinesin family member 11

Strain of Origin

(129X1/SvJ x 129S1/Sv)F1-Kitl

Chromosome

Molecular Note

LoxP sites were introduced to introns 4 and 6. An FRT-flanked neomycin cassette adjacent to the 5' loxP site was removed by Flp recombinase-mediated recombination, leaving exons 5 and 6 flanked by loxP sites.

Husbandry

Suggested Controls

B6129SF2/J, Wild-type from the colony

Breeding Strategy

Heterozygote x Heterozygote

Coat Color

Black

For Research Use Only. Not For Clinical Use.