Product Size
5 mg
25 mg
Custom Size
Product Overview
Description
CBP/p300 bromodomain inhibitor.
Alternative Names
4-[(2S)-1-[2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]propan-2-yl]morpholine
Target
CBP/p300 bromodomain
Biological Description
SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects.
Solubility Overview
DMSO (> 30 mg/mL).
Chemical Properties
Chemical Name
4-[(2S)-1-[2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]propan-2-yl]morpholine
Molecular Weight (Da)
509.00
Molecular Formula
C28H33ClN4O3
SMILES
CC1=C(C(=NO1)C)C2=CC3=C(C=C2)N(C(=N3)CCC4=CC(=C(C=C4)OC)Cl)C[C@H](C)N5CCOCC5
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store in the dark.
