Product Size
25 mg
10 mg
Custom Size
Product Overview
Description
Potent, reversible, competitive ALK5 inhibitor.
Biological Description
Potent, reversible, competitive ALK5 inhibitor (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Inhibits ALK7 but not ALK1, 2, 3, or 6. Shows antifibrotic effects in vivo.
Solubility Overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM.
Chemical Properties
Chemical Name
2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methylpyridine
Molecular Weight (Da)
335.40
Molecular Formula
C20H21N3O2
SMILES
CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
