Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent, selective GSK3 inhibitor.
Biological Description
Potent, selective GSK3 inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Neuroprotective and antioxidant properties. Also able to stimulate glycogen synthesis and gene transcription. Cell-permeable.
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM.
Chemical Properties
Chemical Name
3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione
Molecular Weight (Da)
359.73
Molecular Formula
C16H10ClN3O5
SMILES
O=C2NC(=O)C(=C2Cc1cc(Cl)c(O)cc1)c3ccccc3[N+]([O-])=O
Storage & Handling
Storage Instructions
Store at -20 °C. It is important to note that this product is reported to be light sensitive. Store in the dark. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
