Ryuvidine, KMT5A / SETD8 / Pr-SET7 Inhibitor

Inquiry

Cat. No.

CLIA-0130204

Product Size

1 mg 25 mg Custom Size

Product Overview

Description

Inhibitor of KMT5A / SETD8 / Pr-SET7 that blocks H4K20 monomethylation.

Purity

> 98%

Form

Solid

Alternative Names

2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione; Cdk4 Inhibitor III; Cyclic-dependent Kinase 4 Inhibitor III; SPS812

Target

KMT5A / SETD8 / Pr-SET7

Biological Description

Inhibits (IC50 = 500 nM) KMT5A / SETD8 / Pr-SET7 and suppresses H4JK20 monomethylation in vitro. Weakly active against Cdk4 (IC50 = 6 μM). Induces S-phase accumulation in HEK-293 cells. Cytotoxic towards a number of human cancer cell lines. May induce the DNA damage response.

Source

Synthetic

CAS Number

265312-55-8

Solubility Overview

DMSO: 5 mg/mL.

Chemical Properties

Chemical Name

2-Methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione

Molecular Weight (Da)

284.33

Molecular Formula

C₁₅H₁₂N₂O₂S

PubChem Identifier

481747

SMILES

CC1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)N=C(S3)C

Storage & Handling

Storage Instructions

Shipped at 4 °C. Store at -20 °C long term. Store in the dark.

For Research Use Only. Not For Clinical Use.