Rottlerin, Kinase Inhibitor

Cat. No.
CLIA-0130173
Product Size
50 mg 10 mg Custom Size

Product Overview

Description
Kinase inhibitor.
Purity
> 95%
Form
Solid
Target
Kinase
Biological Description
Originally reported to inhibit PKC isoforms, especially PKCδ and CAM-KIII. Also inhibits MAPKAP-K2 and PRAK (IC50 values are 5.4 and 1.9 μM, respectively), CHK2, PLK1, PIM3 and SRPK1.A potassium channel opener, isolated from Mallotus philippensis. It has a role as an antineoplastic agent, an apoptosis inducer, a metabolite, a K-ATP channel agonist, an antihypertensive agent and an anti-allergic agent.
Source
Synthetic
CAS Number
82-08-6
Solubility Overview
Soluble in DMSO to 100 mM.

Chemical Properties

Chemical Name
3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Molecular Weight (Da)
516.55
Molecular Formula
C30H28O8
PubChem Identifier
SMILES
CC(=O)c4c(O)c(Cc2c(O)c(c1OC(C)(C)C=Cc1c2O)C(=O)/C=C/c3ccccc3)c(O)c(C)c4O

Storage & Handling

Storage Instructions
Shipped at room temperature. Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.

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