Product Size
2 mg
10 mg
Custom Size
Product Overview
Description
Cell-permeable, selective CDK inhibitor.
Alternative Names
(R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol; CYC202; Seliciclib
Biological Description
Cell-permeable, selective inhibitor of cyclin-dependent kinases (CDKs), displaying higher potency and selectivity compared to olomoucine. p34cdc2 inhibitor (IC50 = 0.2 μM). Also inhibits p33cdk2 and p33cdk5. Anti-angiogenic.
Solubility Overview
Soluble in DMSO to 10 mM and in ethanol to 25 mM.
Chemical Properties
Chemical Name
2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
Molecular Weight (Da)
354.46
Molecular Formula
C19H26N6O
SMILES
CC[C@H](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
Storage & Handling
Storage Instructions
Shipped at room temperature. Store at -20 °C. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
