Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
NF-κB inhibitor. Anti-inflammatory agent.
Biological Description
NF-κB inhibitor. Anti-inflammatory agent. Selectively inhibits LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Inhibits TNF-α, IL-1β and IL-6 production. Shows anti-inflammatory effects in vivo. Orally active.
Solubility Overview
Soluble in ethanol to 10 mM and in DMSO to 100mM.
Chemical Properties
Chemical Name
6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
Molecular Weight (Da)
245.26
Molecular Formula
C10H7N5OS
SMILES
O=S(c1nn2nnnc2cc1)c3ccccc3
Storage & Handling
Storage Instructions
Store at -20 °C (desiccating conditions).
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
