Product Size
25 mg
5 mg
Custom Size
Product Overview
Description
Potent cyclin-dependent kinase (CDK) inhibitor.
Biological Description
Ribociclib is a potent cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).
Solubility Overview
Soluble in DMSO to ~10 mM.
Chemical Properties
Chemical Name
7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
Molecular Weight (Da)
434.54
Molecular Formula
C23H30N8O
SMILES
CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C. Store in the dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
