Recombinant NEK2 Mouse Monoclonal Antibody - BSA and Azide Free

Cat. No.: CLAB-00231921

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG1
Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Conjugation
Unconjugated
Applications
WB

Target Information

Target Name
NEK2
UniProt No.
Gene ID
Alternative Names
HSPK 21; HsPK21; NEK 2; NEK2; NEK2_HUMAN; NEK2A; Never in mitosis A-related kinase 2; NIMA (never in mitosis gene a) related kinase 2; NimA like protein kinase 1; NIMA related kinase 2; NimA related protein kinase 2; NimA-like protein kinase 1; NimA-related protein kinase 2; NLK 1; NLK1; Serine/threonine-protein kinase Nek2
Function
Protein kinase that is involved in mitotic regulation. Integral component of the mitotic spindle-assembly checkpoint which is necessary for proper chromosome segregation during metaphase-anaphase transition. Required for association of MAD2L1 to kinetochore. Phosphorylates SGOL1. May have a role at the G2-M transition. May also play a role in meiosis. Isoform 1 but not isoform 2 appears to play a role in centrosome splitting. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
Tissue Specificity
Isoform 1 and isoform 2 are expressed in peripheral blood T-cells and a wide variety of transformed cell types.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Store at 4 °C. Do Not Freeze.
Storage Buffer
100% PBS.

For Research Use Only. Not For Clinical Use.

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