Product Overview
Description
CLPP-00151352 is recombinant Staphylococcus aureus PDF protein, Tagged
Protein Length
Full length protein
Nature
Recombinant Protein
Species
Staphylococcus aureus
Sequence
MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIAKRYGLRSGVGLAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSVQEAYLPTGEGCLSVDDNVAGLVHRHNRITIKAKDIEGNDIQLRLKGYPAIVFQHEIDHLNGVMFYDHIDKNHPLQPHTDAVEV
Sequence Similarities
Belongs to the polypeptide deformylase family.
Predicted Molecular Weight
37 kDa including tags
Target Information
Alternative Names
CG6496; DEFM_HUMAN; mitochondrial; Pdf; PDF1A; Peptide deformylase; Peptide deformylase like protein; Peptide deformylase, mitochondrial; Polypeptide deformylase
Protein Function
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling (By similarity).
Tissue Specificity
Ubiquitous.
Involvement in Disease
Plasma levels are increased in children with concomitant heart disease and failure to thrive but not in children with heart disease and normal body weight.
Shipping & Handling
Constituents
Tris buffer, 50% Glycerol (glycerin, glycerine).
Shipping
Shipped at 4 °C.
Storage
Store at -20 °C or -80 °C.
