Recombinant Human VHL Protein

Cat. No.: CLPP-00151263

Product Size: 100 µg Custom size

Product Overview

Description
CLPP-00151263 is recombinant human VHL protein
Purity
> 95%
Applications
SDS-PAGE
Protein Length
Full length protein
Animal Free
Yes
Nature
Recombinant Protein
Species
Human
Endotoxin Level
< 0.005 Eu/µg
Form
Lyophilized
Sequence
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
Predicted Molecular Weight
24 kDa

Target Information

Protein Name
VHL
UniProt No.
Alternative Names
Elongin binding protein; G7 protein; HRCA 1; HRCA1; Protein G7; pVHL; RCA 1; RCA1; VHL; VHL 1; VHL_HUMAN; VHL1; VHLH; Von Hippel Lindau; Von Hippel Lindau disease tumor suppressor; von Hippel Lindau syndrome; von Hippel Lindau tumor suppressor; Von Hippel Lindau tumor suppressor, E3 ubiquitin protein ligase; Von Hippel-Lindau disease tumor suppressor
Protein Function
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
Tissue Specificity
Expressed in the adult and fetal brain and kidney.
Involvement in Disease
Defects in VHL are cause of susceptibility to pheochromocytoma (PCC); von Hippel-Lindau disease (VHLD); erythrocytosis familial type 2 (ECYT2); renal cell carcinoma (RCC).

Shipping & Handling

Constituents
0.727% Dibasic monohydrogen potassium phosphate, 0.248% Monobasic dihydrogen potassium phosphate, 10.26% TrehaloseBuffer .
Shipping
Shipped at Room Temperature.
Storage
Store at room temperature.

For Research Use Only. Not For Clinical Use.

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