Recombinant Human TWF1/Twinfilin-1 Protein

Cat. No.: CLPP-00151255

Product Size: 50 µg Custom size

Product Overview

Description
CLPP-00151255 is recombinant human TWF1 protein
Purity
> 80%
Applications
SDS-PAGE
Protein Length
Protein fragment
Animal Free
No
Nature
Recombinant Protein
Species
Human
Form
Liquid
Sequence
MGSSHHHHHHSSGLVPRGSHMGSHMMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
Sequence Similarities
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. Contains 2 ADF-H domains.
Predicted Molecular Weight
32 kDa including tags
Tags
His tag N-Terminus

Target Information

Protein Name
TWF1
UniProt No.
Alternative Names
A6; A6 protein tyrosine kinase; MGC105817; MGC23788; MGC41876; Protein A6; Protein tyrosine kinase 9; PTK9; PTK9 protein tyrosine kinase 9; TWF 1; twf1; TWF1_HUMAN; Twinfilin; Twinfilin 1; Twinfilin actin binding protein, homolog 1; Twinfilin, actin-binding protein, homolog 1 (Drosophila); Twinfilin, Drosophila, homolog of, 1; Twinfilin-1
Protein Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.
Tissue Specificity
Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
Involvement in Disease
Defects in TWF1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea

Shipping & Handling

pH
pH: 8.0
Constituents
0.02% DTT, 0.32% Tris HCl, 40% Glycerol (glycerin, glycerine), 0.88% Sodium chloride.
Shipping
Shipped at 4 °C.
Storage
Store at -20 °C or -80 °C.

For Research Use Only. Not For Clinical Use.

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