Recombinant Human SKIP Protein

Cat. No.: CLPP-00151115

Product Size: 2 µg Custom size

Product Overview

Description
CLPP-00151115 is recombinant human INPP5K protein
Applications
ELISA, SDS-PAGE, Western Blot
Protein Length
Full length protein
Animal Free
No
Nature
Recombinant Protein
Species
Human
Form
Liquid
Sequence
MSSRKLSGPKGRRLSIHVVTWNVASAAPPLDLSDLLQLNNRNLNPDIYVIGLQELNSGIISLLSDAAFNDSWSSFLMDVLSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNILDHDLIIWFGDMNFRIEDFGLRFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYIDISNIPTTEDEFLLCYYSNSLRSVVGISRPFQIPPGSLREDPLGEAQPQI
Sequence Similarities
Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.
Predicted Molecular Weight
75 kDa including tags

Target Information

Protein Name
INPP5K
UniProt No.
Alternative Names
43 kDa form skeletal muscle and kidney enriched inositol phosphatase; Inositol polyphosphate 5-phosphatase K; INP5K_HUMAN; INPP5K; muscle and kidney-enriched inositol phosphatase; PPS; skeletal muscle and kidney enriched inositol phosphatase; Skeletal muscle and kidney-enriched inositol phosphatase
Protein Function
Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.
Tissue Specificity
Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
Involvement in Disease
Muscular dystrophy, congenital, with cataracts and intellectual disability (MDCCAID): An autosomal recessive form of muscular dystrophy with onset in early childhood and characterized by progressive muscle weakness. Almost all patients also have early-onset cataracts and intellectual disability of varying severity. Some patients have seizures. The disease is caused by variants affecting the gene represented in this entry.

Shipping & Handling

pH
pH: 8.0
Constituents
0.31% Glutathione, 0.79% Tris HCl.
Shipping
Shipped on dry ice.
Storage
Store at -80 °C.

For Research Use Only. Not For Clinical Use.

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