Product Overview
Description
CLPP-00151102 is recombinant human PTPN6 protein
Applications
Phosphatase Activity, SDS-PAGE
Protein Length
Protein fragment
Nature
Recombinant Protein
Sequence
M-GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ
GRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAW
QENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVT
NCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVL
SFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITY
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Contains 2 SH2 domains. Contains 1 tyrosine-protein phosphatase domain.
Target Information
Alternative Names
70Z-SHP; EC 3.1.3.48; HCP; HCPH; Hematopoietic cell phosphatase; Hematopoietic cell protein tyrosine phosphatase; Hematopoietic cell protein-tyrosine phosphatase; HPTP1C; Protein tyrosine phosphatase 1C; Protein tyrosine phosphatase non receptor type 6; Protein tyrosine phosphatase SHP1; Protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP 1; Protein-tyrosine phosphatase SHP-1; PTN6_HUMAN; PTP 1C; PTP-1C; PTP1C; Ptpn6; SH PTP 1; SH PTP1; SH-PTP1; SHP 1; SHP 1L; SHP1; SHP1L; tyrosine protein phosphatase non receptor type 6; Tyrosine-protein phosphatase non-receptor type 6
Protein Function
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Tissue Specificity
Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Shipping & Handling
Constituents
0.0156% Beta mercaptoethanol, 0.0154% DTT, 0.395% Tris HCl, 0.0292% EDTA, 20% Glycerol (glycerin, glycerine).
Shipping
Shipped at 4 °C.
