Product Overview
Description
CLPP-00150899 is recombinant human NDE1 protein, Tagged
Protein Length
Full length protein
Nature
Recombinant Protein
Sequence
MEDSGKTFSSEEEEANYWKDLAMTYKQRAENTQEELREFQEGSREYEAELETQLQQIETRNRDLLSENNRLRMELETIKEKFEVQHSEGYRQISALEDDLAQTKAIKDQLQKYIRELEQANDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQELAVQQKQEKPRTPMPSSVEAERTDTAVQATGSVPSTPIAHRGPSSSLNTPGSFRRGLDDSTGGTPLTPAARISALNIVGDLLRKVGALESKLASCRNLVYDQSPNRTGGPASGRSSKNRDGGERRPSSTSVPLGDKGLDTSCRWLSKSTTRSSSSC
Sequence Similarities
Belongs to the nudE family.
Predicted Molecular Weight
63 kDa
Target Information
Alternative Names
FLJ20101; HOM TES 87; LIS1 interacting protein NUDE1; LIS1 interacting protein NUDE1rat homolog; LIS4; NDE 1; NDE1; NDE1_HUMAN; Nuclear distribution gene E homolog 1; Nuclear distribution protein nudE homolog 1; NudE; NUDE 1; NudE nuclear distribution gene E homolog 1; NudE nuclear distribution gene E homolog 1 (A. nidulans); NUDE1
Protein Function
Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.
Involvement in Disease
Lissencephaly 4 (LIS4): A neurodevelopmental disorder characterized by lissencephaly, severe brain atrophy, extreme microcephaly, and profound intellectual disability. The disease is caused by variants affecting the gene represented in this entry. Microhydranencephaly (MHAC): A severe neurodevelopmental disorder characterized by microcephaly, severe motor and intellectual disability, spasticity, and brain malformations that include gross dilation of the ventricles with complete absence of the cerebral hemispheres or severe delay in their development. The disease is caused by variants affecting the gene represented in this entry.
Shipping & Handling
Constituents
0.79% Tris HCl, 0.31% Glutathione.
Shipping
Shipped on Dry Ice.
