Product Overview
Description
CLPP-00150897 is recombinant human NCK1 protein
Applications
HPLC, SDS-PAGE
Protein Length
Full length protein
Nature
Recombinant Protein
Endotoxin Level
< 1.000 Eu/µg
Sequence
MGSSHHHHHHSSGLVPRGSHMAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKHLS
Sequence Similarities
Contains 1 SH2 domain. Contains 3 SH3 domains.
Predicted Molecular Weight
43 kDa
Target Information
Alternative Names
Cytoplasmic protein NCK1; Melanoma Nck protein; MGC12668; NCK; NCK 1; NCK adaptor protein 1; NCK alpha; NCK tyrosine kinase; Nck-1; NCK1; NCK1_HUMAN; NCKalpha; Non catalytic region of tyrosine kinase; SH2/SH3 adaptor protein NCK alpha; SH2/SH3 adaptor protein NCK-alpha
Protein Function
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2.
Shipping & Handling
Constituents
0.24% Tris, 0.29% Sodium chloride. Supplied as a 0.2 µM filtered solution.
Shipping
Shipped at 4 °C.
Storage
Stored with a carrier protein are stable for at least 3 months at -20 °C to -80 °C.
