Recombinant Human LMCD1 Protein

Cat. No.: CLPP-00150831

Product Size: 10 µg Custom size

Product Overview

Description
CLPP-00150831 is recombinant human LMCD1 protein, His tag
Purity
> 95%
Applications
HPLC, SDS-PAGE
Protein Length
Full length protein
Animal Free
No
Nature
Recombinant Protein
Species
Human
Endotoxin Level
< 1.000 Eu/µg
Form
Liquid
Sequence
MGSSHHHHHHSSGLVPRGSHMAKVAKDLNPGVKKMSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLRPRCSGCDEIIFAEDYQRVEDLAWHRKHFVCEGCEQLLSGRAYIVTKGQLLCPTCSKSKRSLEHHHHHH
Sequence Similarities
Contains 2 LIM zinc-binding domains. Contains 1 PET domain.
Predicted Molecular Weight
44 kDa including tags
Tags
His tag C-Terminus
,
His tag N-Terminus

Target Information

Protein Name
LMCD1
UniProt No.
Alternative Names
Dyxin; LIM and cysteine rich domains 1; LIM and cysteine rich domains protein 1; LIM and cysteine-rich domains protein 1; LMCD1; LMCD1_HUMAN
Protein Function
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T cells signaling pathway.
Tissue Specificity
Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle.

Shipping & Handling

pH
pH: 7.4
Constituents
100% PBS.
Shipping
Shipped on Dry Ice.
Storage
Store at -20 °C or -80 °C.

For Research Use Only. Not For Clinical Use.

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