Recombinant Human GFAP Protein

Cat. No.: CLPP-00150726

Product Size: 10 µg Custom size

Product Overview

Description
CLPP-00150726 is recombinant human GFAP protein
Purity
> 95%
Applications
SDS-PAGE
Protein Length
Protein fragment
Animal Free
No
Nature
Recombinant Protein
Species
Human
Endotoxin Level
< 1.000 Eu/µg
Form
Lyophilized
Sequence
MGSSHHHHHHSSGLVPRGSHMLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
Sequence Similarities
Belongs to the intermediate filament family.
Predicted Molecular Weight
19 kDa including tags
Tags
His tag N-Terminus

Target Information

Protein Name
GFAP
UniProt No.
Alternative Names
wu:fb34h11; ALXDRD; cb345; etID36982.3; FLJ42474; FLJ45472; GFAP; GFAP_HUMAN; gfapl; Glial fibrillary acidic protein; Intermediate filament protein; wu:fk42c12; xx:af506734; zgc:110485
Protein Function
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Tissue Specificity
Expressed in cells lacking fibronectin.
Involvement in Disease
Defects in GFAP are a cause of Alexander disease (ALEXD). Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.

Shipping & Handling

Constituents
99% Phosphate Buffer, 0.88% Sodium chloride.
Shipping
Shipped at 4 °C.
Storage
Store at -80 °C.

For Research Use Only. Not For Clinical Use.

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