Recombinant Human Gelsolin Protein

Cat. No.: CLPP-00150725

Product Size: 10 µg Custom size

Product Overview

Description
CLPP-00150725 is recombinant human GSN protein, His tag
Purity
> 90%
Applications
Mass Spectrometry, SDS-PAGE, Western Blot
Protein Length
Protein fragment
Animal Free
No
Nature
Recombinant Protein
Species
Human
Form
Liquid
Sequence
GLGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA
Sequence Similarities
Belongs to the villin/gelsolin family. Contains 6 gelsolin-like repeats.
Predicted Molecular Weight
42 kDa including tags
Tags
His tag C-Terminus

Target Information

Protein Name
GSN
UniProt No.
Alternative Names
Actin depolymerizing factor; Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; GELS_HUMAN; Gelsolin; Gsn
Protein Function
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Tissue Specificity
Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Involvement in Disease
Defects in GSN are the cause of amyloidosis type 5 (AMYL5); also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

Shipping & Handling

Constituents
0.33% Sodium phosphate, 2.9% Sodium chloride.
Shipping
Shipped at 4 °C.
Storage
Store at -80 °C.

For Research Use Only. Not For Clinical Use.

Online Inquiry