Product Overview
Description
CLPP-00150660 is recombinant human EMD protein
Applications
ELISA, Peptide Array, SDS-PAGE, Western Blot
Protein Length
Full length protein
Nature
Recombinant Protein
Sequence
MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRLSPPSSSAASSYSFSDLNSTRGDADMYDLPKKEDALLYQSKGYNDDYYEESYFTTRTYGEPESAGPSRAVRQSVTSFPDADAFHHQVHDDDLLSSSEEECKDRERPMYGRDSAYQSITHYRPVSASRSSLDLSYYPTSSSTSFMSSSSSSSSWLTRRAIRPENRAPGAGLGQDRQVPLWGQLLLFLVFVIVLFFIYHFMQAEEGNPF
Sequence Similarities
Contains 1 LEM domain.
Predicted Molecular Weight
54 kDa including tags
Target Information
Alternative Names
EDMD; Emd; EMD_HUMAN; Emerin; Emery Dreifuss muscular dystrophy; STA
Protein Function
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Tissue Specificity
Skeletal muscle, heart, colon, testis, ovary and pancreas.
Involvement in Disease
Defects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 (EDMD1). A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.
Shipping & Handling
Constituents
0.31% Glutathione, 0.79% Tris HCl. Reduced glutathione.
Shipping
Shipped on dry ice.
