Product Overview
Description
CLPP-00150983 is recombinant human CBY1 protein
Protein Length
Full length protein
Nature
Recombinant Protein
Sequence
MASMTGGQQMGRGHHHHHHENLYFQGPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDMLSESTAESHLMEKELDELRISRKRK
Predicted Molecular Weight
17 kDa including tags
Sequence Similarities
Belongs to the chibby family.
Tags
His-T7 tag N-Terminus
Target Information
Alternative Names
ARPP-binding protein; C22orf2; CBY; Cby1; CBY1_HUMAN; Cytosolic leucine rich protein; Cytosolic leucine-rich protein; Golgi and endoplasmic reticulum-associated 1; HRIHFB2025; PIGEA 14; PIGEA-14; PKD2 interactor; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1; Protein Chibby; Protein chibby homolog 1
Protein Function
Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Tissue Specificity
Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
Shipping & Handling
Shipping
Shipped at 4 °C.
Constituents
0.87% Tris HClContains NaCl, KCl, EDTA, arginine, DTT and glycerol.
