Recombinant CCDC88A Rabbit Monoclonal Antibody - BSA and Azide Free

Cat. No.: CLAB-00231813

Product Size: 20 µL 100 µL Custom Size

Product Overview

Applications
Flow Cyt (Intra), ICC/IF, IP, WB
Isotype
IgG
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Host Species
Rabbit
Conjugation
Unconjugated
Clone Number
EPR18433

Target Information

Alternative Names
AKT iphosphorylation enhancer; Akt phosphorylation enhancer; APE; Ccdc88a; Coiled coil domain containing 88A; Coiled coil domain containing protein 88A; Coiled-coil domain-containing protein 88A; FLJ10392; G alpha interacting vesicle associated protein; G alpha-interacting vesicle-associated protein; Galpha interacting vesicle associated protein; Girders of actin filament; Girdin; GIV; GRDN; GRDN_HUMAN; HkRP1; Hook related protein 1; Hook-related protein 1; KIAA1212
UniProt No.
Tissue Specificity
Expressed ubiquitously.
Target Name
CCDC88A
Gene ID
Function
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase -dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Store at 4 °C. Do Not Freeze.
Storage Buffer
PBS. pH: 7.2.

For Research Use Only. Not For Clinical Use.

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