Product Overview
Description
BLOC1S2 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normalbiogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet densegranules.
Applications
Antibody Competition
Nature
Recombinant Protein
Sequence
AAEGVLATRSDEPARDDAAVETAEEAKEP
Predicted Molecular Weight
21 kDa
Target Information
Alternative Names
biogenesis of lysosomal organelles complex-1, subunit 2; BLOC-1 subunit 2; CEAP; centrosomal 10 kDa protein; centrosome protein oncogene; Centrosome-associated protein; subunit 2
Protein Function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.
Shipping & Handling
Constituents
PBS and 1M Urea, pH 7.4.
Shipping
Shipped on dry ice.
