Recombinant ACTR1A Protein

Cat. No.: CLPP-00150002

Product Size: 100 μL Custom size

Product Overview

Description
The actin-related protein ACTR1A, a member of the superfamily of actin-related proteins, is the major subunit of the dynactin complex, a key component of the cytoplasmic dynein motor machinery. The major components of the dynactin complex, consisting of at least ten polypeptides, include ACTR1A. ACTR1A, the most abundant subunit in the dynactin complex, is most similar to conventional actin (>50% amino acid identity). The dynactin complex has been shown to localize to multiple structures within the cell, including membrane organelles, the centrosome, spindle poles, and spindle pole microtubules during mitosis and prometaphase kinetochores. It regulates dyneinmediated vesicle movement on microtubules as well as spindle assembly and cell division. ACTR1A overexpression in cells results in aberrant spindle morphologies and cell cycle delay at prometaphase, suggesting a possible function of ACTR1A/dynactin complex in progression through the prometaphase of mitosis.
Purity
> 80%
Applications
Antibody Competition
Nature
Recombinant Protein
Sequence
SLDTFKKMWVSKKEYEEDGARSIHRK
Predicted Molecular Weight
21 kDa

Target Information

Protein Name
ACTR1A
UniProt No.
Alternative Names
Actin-RPV; alpha-centractin; ARP1 (actin-related protein 1, yeast) homolog A (centractin alpha); ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); ARP1actin-RPV; centractin; Centrosome-associated actin homolog; CTRN1; FLJ52695; FLJ52800; FLJ55002
Protein Function
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Shipping & Handling

Constituents
PBS and 1M Urea, pH 7.4.
Shipping
Shipped on dry ice.
Storage
Store at -20 °C.

For Research Use Only. Not For Clinical Use.

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