Product Overview
Reactivity
Human, Mouse, Rat
Target Information
Alternative Names
14 3 3; 14 3 3 protein beta; 14 3 3 protein beta/alpha; 14 3 3 protein zeta; 14 3 3 zeta; 14-3-3 protein beta/alpha; 14-3-3 protein/cytosolic phospholipase A2; 1433B_HUMAN; GW128; HS1; KCIP 1; KCIP-1; MGC111427; MGC126532; MGC138156; N-terminally processed; Protein 1054; Protein kinase C inhibitor protein 1; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; Tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; YWHAB; YWHAD; YWHAZ
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Store at -20 °C. Stable for 12 months at -20 °C.
Storage Buffer
40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant. pH: 7.2.
Preservative
0.05% Sodium Azide
