Raloxifene Hydrochloride, Estrogen Receptor Modulator (SERM)

Inquiry

Cat. No.

CLIA-0130174

Product Size

1 g 200 mg Custom Size

Product Overview

Description

Selective estrogen receptor modulator (SERM).

Purity

> 98%

Form

Solid

Target

Estrogen receptor (SERM)

Biological Description

Selective estrogen receptor modulator (SERM). Binds to both ERα (Kd = 90pM) and ERβ. Tissue-dependently inhibits or activates ER-induced transcription. Inhibits estradiol-induced progesterone receptor activity in hypothalamic cells (IC50 = 1nM). Orally Active.

Source

Synthetic

CAS Number

82640-04-8

Solubility Overview

Soluble in DMSO 50 mM.

Chemical Properties

Chemical Name

[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone hydrochloride

Molecular Weight (Da)

510.05

Molecular Formula

C₂₈H₂₇NO₄S.HCl

PubChem Identifier

54900

SMILES

C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.Cl

Storage & Handling

Storage Instructions

Store at room temperature. The product can be stored for up to 12 months.

Handling

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.