Product Size
1 mg
5 mg
Custom Size
Product Overview
Description
Potent, irreversible PI3-kinase inhibitor.
Alternative Names
DJM-166; DJM-2-166; Sonolisib
Biological Description
Potent, irreversible PI3-kinase inhibitor. Inhibits purified phosphoinositide (PtdIns)-3-kinase (IC50 = 0.1 nM) and PtdIns-3-kinase signaling as assessed by phospho-Ser473-Akt levels in HT-29 colon cancer cells (IC50 = 20 nM). Ring-opened analog of wortmannin. Displays antitumor activity.
Solubility Overview
Soluble in DMSO to 50 mM.
Chemical Properties
Chemical Name
[(3aR,6E,9S,9aR,10R,11aS)-6-[[Bis(prop-2-enyl)amino]methylidene]-5-hydroxy-9-(methoxymethyl)-9a,11a-dimethyl-1,4,7-trioxo-2,3,3a,9,10,11-hexahydroindeno[4,5-h]isochromen-10-yl] acetate
Molecular Weight (Da)
525.59
Molecular Formula
C29H35NO8
SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(CC=C)CC=C)/C4=C(C3=O)O)COC)C)C
Storage & Handling
Storage Instructions
Shipped at room temperature. Store at -20 °C. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
