Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent CDK inhibitor.
Biological Description
Potent CDK inhibitor (IC50 = 100 nM for CDK2/cyclin A). Also inhibits other kinases in the low micromolar range, including DYRK1A and RSK1 (IC50 values are 0.3 and 1.49 μM, respectively).
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM.
Chemical Properties
Chemical Name
(R)-2-[6-(3-Chlorophenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methylbutan-1-ol
Molecular Weight (Da)
388.90
Molecular Formula
C19H25ClN6O
SMILES
CC(C)[C@H](CO)Nc2nc(Nc1cccc(Cl)c1)c3ncn(c3n2)C(C)C
Storage & Handling
Storage Instructions
Store at 4 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
