Product Overview
Reactivity
Human, Mouse, Rat
Applications
IHC, IHC-Fr, IHC-P, WB
Target Information
Alternative Names
PSEN2; AD3LP; AD4; AD5; AD3L; CMD1V; PS-2; PSNL2; PS2; STM2; Presenilin 2; STM-2; E5-1; Presenilin-2
Function
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
Tissue Specificity
Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Prior to reconstitution, 4 °C. Following reconstitution store at -20 °C. Avoid freeze-thaw cycles.
