Product Size
1 mg
5 mg
Custom Size
Product Overview
Description
Potent, selective and ATP-competitive mTOR inhibitor.
Biological Description
Potent, selective and ATP-competitive mTOR inhibitor (IC50 = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1/eIF-4E/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC50 values are 0.1 (p110γ), 0.41 (DNA-PK), 1.27 (p110δ), 1.96 (p110α) and 2.2 (p110β) μM). Anticancer agent. Active in vivo and in vitro.
Solubility Overview
Soluble in DMSO to 25 mM.
Chemical Properties
Chemical Name
(2E)-2-(4-Amino-1-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-3-ylidene)indol-5-ol
Molecular Weight (Da)
308.34
Molecular Formula
C16H16N6O
SMILES
CC(C)N1C2=C(C(=C3C=C4C=C(C=CC4=N3)O)N1)C(=NC=N2)N
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
