PLK1 Mouse Monoclonal Antibody

Cat. No.: CLAB-00231346

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG2a
Reactivity
Human, Xenopus laevis
Clonality
Monoclonal
Host Species
Mouse
Conjugation
Unconjugated
Applications
WB

Target Information

Target Name
PLK1
UniProt No.
Gene ID
Alternative Names
Cell cycle regulated protein kinase; PLK 1; PLK; PLK-1; plk1; PLK1_HUMAN; Polo like kinase 1; Polo-like kinase 1; Serine/threonine protein kinase 13; Serine/threonine protein kinase PLK1; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK 13; STPK13
Function
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.
Tissue Specificity
Placenta and colon.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Store at 4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C or -80 °C. Avoid freeze / thaw cycle.
Storage Buffer
PBS.

For Research Use Only. Not For Clinical Use.

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