Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Inhibitor of p53-mediated apoptosis.
Alternative Names
Antigen NY-CO-13; BCC7; Cellular tumor antigen p53; FLJ92943; LFS1; Mutant tumor protein 53; NSC 303580; p53; p53 tumor suppressor; P53_HUMAN; Phosphoprotein p53; Tp53; Transformation related protein 53; TRP53; tumor antigen p55; Tumor protein 53; Tumor protein p53; Tumor suppressor p53
Target
p53-mediated apoptosis
Biological Description
An inhibitor of p53-mediated apoptosis. Prevents p53 binding at the mitochondrial surface without affecting p53 transactivational activities. Pifithrin-μ reduces p53-mediated apoptosis triggered by nutlin; also interacts selectively with HSP70, disrupting its association with many substrate proteins.
Solubility Overview
Soluble in ethanol to 75 mM and in DMSO to 75 mM.
Chemical Properties
Chemical Name
2-Phenylethynesulfonamide
Molecular Weight (Da)
181.21
Molecular Formula
C8H7NO2S
SMILES
O=S(C#CC1=CC=CC=C1)(N)=O
Storage & Handling
Storage Instructions
Store at 4 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
