Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor.
Target
Casein kinase 1 epsilon (CK1 epsilon) and CK1 delta
Biological Description
Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM for CK1ε and CK1δ, respectively). Shows >300-fold selectivity over CK2 and selectivity over more than 40 other kinases. Alters circadian rhythms in vivo.Also available in simple stock solutions - add 1 mL of water to get an exact, ready-to-use concentration.
Solubility Overview
Soluble in water to 100 mM and in DMSO to 100 mM.
Chemical Properties
Chemical Name
4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride
Molecular Weight (Da)
410.32
Molecular Formula
C19H20FN5.2HCl
SMILES
Cl.Cl.Nc1nccc(n1)c3c(ncn3C2CCCCC2)c4ccc(F)cc4
Storage & Handling
Storage Instructions
Store at room temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
