Product Size
5 mg
25 mg
Custom Size
Product Overview
Description
Competitive inhibitor of Chk1.
Biological Description
PF-477736 is a proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects. It has a role as a non-specific serine/threonine protein kinase inhibitor and an antineoplastic agent.
Solubility Overview
Soluble in DMSO to 50 mM.
Chemical Properties
Chemical Name
(R)-α-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide
Molecular Weight (Da)
419.48
Molecular Formula
C22H25N7O2
SMILES
CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)C(C5CCCCC5)N
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
