PD0332991, Cdk4/Cdk6 Inhibitor

Cat. No.
CLIA-0130210
Product Size
5 mg 25 mg Custom Size

Product Overview

Description
Potent, highly specific CDK4/CDK6 inhibitor.
Purity
> 98%
Form
Solid
Alternative Names
Palbociclib; PD-0332991
Target
CDK4/CDK6
Biological Description
Potent, highly specific inhibitor of Cdk4 (IC50 = 11 nM) and Cdk6 (IC50 = 16 nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases (IC50 values are > 10 μM).  Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines. Blocks growth of intracranial glioblastoma multiforme xenografts in mice. Blood-brain barrier permeable.
Source
Synthetic
CAS Number
571190-30-2
Solubility Overview
Soluble in DMSO.

Chemical Properties

Chemical Name
6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
Molecular Weight (Da)
447.53
Molecular Formula
C24H29N7O2
PubChem Identifier
SMILES
CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C

Storage & Handling

Storage Instructions
Shipped at 4 °C. Store at -20 °C. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.

Online Inquiry