Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent, highly selective ATP non-competitive MEK1/2 inhibitor.
Alternative Names
PD184352
Biological Description
Potent, highly selective ATP non-competitive MEK1/2 inhibitor. Prevents ERK phosphorylation (IC50 = 100-500 nM) and subsequent signalling. Enhances cisplatin dependent apoptosis. Shows antitumor effects in vivo. Orally active.
Solubility Overview
Soluble in DMSO 100 mM and in ethanol to 25 mM.
Chemical Properties
Chemical Name
2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy-3,4-difluorobenzamide
Molecular Weight (Da)
478.66
Molecular Formula
C17H14ClF2IN2O2
SMILES
c1cc(c(cc1I)Cl)Nc2c(ccc(c2F)F)C(=O)NOCC3CC3
Storage & Handling
Storage Instructions
Store at 4 °C. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
