Product Size
1 mL
5 mL
Custom Size
Product Overview
Description
Potent MEK1 and MEK2 inhibitor.
Alternative Names
PD0325901, Mirdametinib, (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide
Biological Description
PD-0325901 is an orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD-0325901 selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.
Solubility Overview
A 5 mM sterile-filtered solution in DMSO.
Chemical Properties
Chemical Name
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
Molecular Weight (Da)
482.19
Molecular Formula
C16H14F3IN2O4
SMILES
C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
