Product Size
5 mg
1 mg
Custom Size
Product Overview
Description
CDK/cyclin inhibitor.
Biological Description
CDK/cyclin inhibitor (IC50 values are 7.6 (CDK1/cyclin B), 0.1 (CDK2/cyclin E), 19.8 (CDK4/cyclin D1), 0.45 (CDK7/cyclin H) and 0.06 (CDK9/cyclin T) μM). Shows an IC50 of >100 μM for 10 other kinases. Antiproliferative and anticancer activity in vitro.
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM.
Chemical Properties
Chemical Name
2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-[purin-6-yl]amino]methyl]phenol
Molecular Weight (Da)
370.45
Molecular Formula
C19H26N6O2
SMILES
Oc3ccccc3CNc2nc(nc1c2ncn1C(C)C)N[C@H](CC)CO
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
