NVP-BEZ235, PI3K and mTOR Inhibitor

Cat. No.
CLIA-0130188
Product Size
5 mg 25 mg Custom Size

Product Overview

Description
Potent PI3K and mTOR inhibitor.
Purity
> 98%
Form
Solid
Alternative Names
BEZ-235; BEZ235; Dactolisib
Target
PI3K and mTOR
Biological Description
Potent, ATP-competitive Phosphatidylinositol 3-kinase (PI3K) inhibitor (IC50 = 4, 5, 7 and 75 nM for PI3Kα, -γ, -δ, and -β respectively) and mTOR inhibitor. Able to directly induce G1 arrest and inhibit angiogenesis in vitro and potentiate the efficacy of other anticancer agents in vivo.
Source
Synthetic
CAS Number
915019-65-7

Chemical Properties

Chemical Name
2-Methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile
Molecular Weight (Da)
469.54
Molecular Formula
C30H23N5O
PubChem Identifier
SMILES
CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

Storage & Handling

Storage Instructions
Shipped at room temperature. Store at -20 °C. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.

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