Product Size
5 mg
1 mg
Custom Size
Product Overview
Description
Potent CDK1/cyclin B and CDK2/cyclin A3 inhibitor. Antiproliferative agent.
Target
CDK1/cyclin B and CDK2/cyclin A3
Biological Description
Potent CDK1/cyclin B and CDK2/cyclin A3 inhibitor (IC50 values are 9.5 and 5.4 nM for CDK1/cyclin B and CDK2/cyclin A3 respectively). Antiproliferative agent. Inhibits CDK4/D1, DYRK1A, PDK1 ROCKII (IC50 values are 1.6, 0.9, 0.8 and 0.6 μM respectively). Induces G2/M cell cycle arrest. Shows antitumor effects in vivo.
Solubility Overview
Soluble in DMSO to 50 mM.
Chemical Properties
Chemical Name
4-[[6-(Cyclohexylmethoxy)-7H-purin-2-yl]amino]benzenesulfonamide
Molecular Weight (Da)
402.47
Molecular Formula
C18H22N6O3S
SMILES
C1CCC(CC1)COC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)S(=O)(=O)N
Storage & Handling
Storage Instructions
Store at -20 °C. Store in the dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
