NSC697923, UBE2N Inhibitor

Cat. No.
CLIA-0130190
Product Size
25 mg 5 mg Custom Size

Product Overview

Description
Selective, cell-permeable UBE2N inhibitor.
Purity
> 98%
Form
Solid
Target
UBE2N
Biological Description
Selective, cell-permeable UBE2N inhibitor. Inhibits E2 complex Ubc13-Uev1A. Inhibits NF-κB activation. Induces nuclear accumulation of p53 and apoptosis. Shows potent cytotoxic effects to neuroblastoma cell lines. Shows antitumor effects in vivo.
Source
Synthetic
CAS Number
343351-67-7
Solubility Overview
Soluble in ethanol to 25 mM (with gentle warming) and in DMSO to 100 mM.

Chemical Properties

Chemical Name
2-(4-Methylphenyl)sulfonyl-5-nitrofuran
Molecular Weight (Da)
267.26
Molecular Formula
C11H9NO5S
PubChem Identifier
SMILES
CC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(O2)[N+](=O)[O-]

Storage & Handling

Storage Instructions
Store at -20 °C. It is important to note that this product is reported to be light sensitive. Store in the dark. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.

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