Product Overview
Reactivity
Human, Mouse, Rat
Applications
IHC, IHC-P, WB
Target Information
Alternative Names
Glycogen synthase kinase 3 beta-interacting protein; GSK3B-interacting protein; hNinein; KIAA1565; ninein (GSK3B interacting protein); ninein Centrosomal protein; ninein
Function
Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Required for centriole organization and microtubule anchoring at the mother centriole.
Tissue Specificity
Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Store at -20 °C. Avoid freeze-thaw cycles.
Storage Buffer
PBS (pH 7.3), 50% glycerol.
Preservative
0.02% Sodium Azide
