Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent 5-HT2A antagonist.
Biological Description
Potent 5-HT2A receptor antagonist (Ki = 7.1 nM for inhibition of [3H] ketanserin binding in rat cortex). Additionally blocks α1 adrenoceptors (Ki values are 5.5 and 84 nM at α1 and α2, respectively). Acts as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) (Ki values are 220 and 555 nM at rat SERT and NET, respectively). Antidepressant.
Solubility Overview
Soluble in DMSO to 25 mM, in ethanol to 10 mM and in 1 eq. HCl to 10 mM.
Chemical Properties
Chemical Name
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
Molecular Weight (Da)
506.47
Molecular Formula
C25H32ClN5O2.HCl
SMILES
Cl.Clc1cccc(c1)N4CCN(CCCN3N=C(CC)N(CCOc2ccccc2)C3=O)CC4
Storage & Handling
Storage Instructions
Store at room temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
