Necdin Rabbit Polyclonal Antibody

Cat. No.: CLAB-00231196

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG
Reactivity
Mouse (predicted: Human)
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
Unconjugated
Applications
IHC-Fr, WB

Target Information

Target Name
NDN
UniProt No.
Gene ID
Alternative Names
HsT16328; NDN; NECD_HUMAN; Necdin; Necdin homolog; Necdin MAGE family member; necdin related protein; PWCR
Function
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences.
Tissue Specificity
Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Store at 4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C long term. Avoid freeze / thaw cycle.
Storage Buffer
PBS, 50% Glycerol (glycerin, glycerine)Filter-sterilized. No additive. pH: 6.5.

For Research Use Only. Not For Clinical Use.

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