NCB-0846, TNIK Inhibitor

Inquiry

Cat. No.

CLIA-0130219

Product Size

1 mg 5 mg Custom Size

Product Overview

Description

A potent TNIK inhibitor.

Purity

> 98%

Form

Solid

Alternative Names

cis-4-(2-(3H-Benzo[d]imidazol-5-ylamino)quinazolin-8-yloxy)cyclohexanol; SCHEMBL18045467

Target

TNIK

Biological Description

A potent small-molecule TNIK (Traf2 and Nck-interacting protein kinase) inhibitor, having anti-Wnt activity and suppressing Wnt-driven intestinal tumorigenesis. Also inhibits FLT3, JAK3, PDGFRa, TRKA, CDK2/CycA2, and HGK. NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice

CAS Number

1792999-26-8

Solubility Overview

> 30 mg/mL in DMSO.

Chemical Properties

Chemical Name

4-[2-(3H-benzimidazol-5-ylamino)quinazolin-8-yl]oxycyclohexan-1-ol

Molecular Weight (Da)

375.42

Molecular Formula

C₂₁H₂₁N₅O₂

PubChem Identifier

91801204

SMILES

C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5

Storage & Handling

Storage Instructions

Shipped at 4 °C. Store at -20 °C. Store in the dark.

For Research Use Only. Not For Clinical Use.