Mz1, Selectively Degrades BRD4

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Cat. No.

CLIA-0130120

Product Size

500 μg 100 μg Custom Size

Product Overview

Description

(+)-JQ1 based PROTAC that selectively degrades BRD4.

Purity

> 98%

Form

Solid

Target

BRD4

Biological Description

Cell penetrant PROTAC (Proteolysis Targeting Chimera) compound based on (+)-JQ1 (ab141498) tethered to a von Hippel-Lindau (VHL) ligand. Retains high affinity for BRD2, BRD3 and BRD4 bromodomains. Induces preferential degradation of BRD4 over BRD2 and BRD3 in HeLa cells.

Source

Synthetic

CAS Number

1797406-69-9

Chemical Properties

Chemical Name

(2S,4R)-1-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2- f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Molecular Weight (Da)

1002.64

Molecular Formula

C₄₉H₆₀ClN₉O₈S₂

PubChem Identifier

122201421

SMILES

CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCOCCOCCOCC(=O)NC(C(=O)N4CC(CC4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)C7=CC=C(C=C7)Cl)C

Storage & Handling

Storage Instructions

Shipped at 4 °C. Store at -20 °C.

For Research Use Only. Not For Clinical Use.